Endocrine Abstracts

The prostate specific membrane antigen (PSMA) has been reported to be selectively overexpressed in the tumor-associated neovasculature of a wide variety of solid tumors including breast carcinoma, and growth and progression of breast cancers are accompanied by increased neovascularization (angiogenesis). In this context, the robust expression of PSMA by breast cancer lesions as evidenced using PSMA-PET/CT makes PSMA an interesting potential target for antiangiogenic therapy of...

Background: The current focus of personalized medicine is towards the use of the theranostic approach – the development of an interdependent, collaborative targeted therapeutic and a companion diagnostic test. [DOTA0,D-Phe1,Tyr3]-octreotate (DOTA-TATE) and ligands targeting prostate-specific membrane antigen (PSMA) have been introduced recently as 177Lu-labeled theranostics for neuroendocrine tumors and prostate cancer respectiv...